Galectin sialic acid cell adhesion lymphoma
WebMar 4, 2014 · Galectin-1 is known to be one of the extracellular matrix proteins. To elucidate the biological roles of galectin-1 in cell adhesion and invasion of human anaplastic large cell lymphoma, we performed cell adhesion and invasion assays using the anaplastic large cell lymphoma cell line H-ALCL, which was previously established in our … WebDOI: 10.3892/ijo.2015.3211. Abstract. To determine the biological roles of cell surface glycosylation, we modified the surface glycosylation of human malignant lymphoma …
Galectin sialic acid cell adhesion lymphoma
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WebFeb 15, 1999 · Recently, a subset of immunoglobulin superfamily receptors has been found to behave as sialic acid binding lectins and proposed to define a new class of adhesion … WebGlycans linked to surface proteins are the most complex biological macromolecules that play an active role in various cellular mechanisms. This diversity is the basis of cell–cell interaction and communication, cell growth, cell migration, as well as co-stimulatory or inhibitory signaling. Our review describes the importance of neuraminic acid and its …
Web), which is found mainly on N-glycans and, to a lesser extent, on O-glycans.In this minireview, we summarize the evidence suggesting that ST6Gal-I-mediated α2,6-sialylation inhibits binding of N-glycans to galectin-type lectins, thereby serving as a negative regulator of galectin-dependent cell responses (of note, α2,6-sialic acid/siglec interactions, … WebMay 23, 2016 · Suzuki and colleagues have also demonstrated that pretreatment of H-ALCL cells with neuraminidase, which cleaves cell surface sialic acid, increases galectin-3 adhesion to integrins . Carbohydrate-binding characteristics of galectins involve (i) the array of glycan ligands; (ii) the architecture, dynamics, and binding sites of CRDs; and (iii ...
WebApr 27, 2024 · Galectin family classification and structure of galectin-3 (Gal-3). a Based on their structures, the galectin family has been subdivided into three subtypes: prototype galectins, chimaera-type galectins and tandem-repeat-type galectins. Some galectins can form dimers or oligomers. b The Gal-3 protein structure consists of an N-terminal domain … WebSep 26, 2024 · Terminal sialic acid and fucose are present in some forms of LGALS3BP [3, 8, 10, 42, 60, 83, 85, 87]. ... they proved a role for LGALS3BP in mediating lymphoma cell resistance to chemotherapy. ... Going deep in understanding LGALS3BP involvement in galectin-3- mediated cell adhesion, authors were able to demonstrate for the first time …
WebFeb 1, 2006 · In the present study, we analyzed the regulatory roles of cell surface sialylation in cell adhesion to galectin-1 in the human diffuse large B cell lymphoma …
WebJun 23, 1998 · The 6′PAA-B probe was used to detect lectin activity on a B lymphoma cell line, Daudi, which expresses cell surface CD22 (Fig. 2 A ). These cells, unlike CHO … food near buda txWebMar 4, 2014 · Galectin-1 is known to be one of the extracellular matrix proteins. To elucidate the biological roles of galectin-1 in cell adhesion and invasion of human anaplastic large cell lymphoma, we ... e-learning based on cloud computingWebApr 13, 2024 · Sialic acids are a family of acidic nine-carbon sugars typically found at the terminal position of glycoproteins or glycolipids on the cell surface or secreted by cells [].Because of their outermost position on glycan chains, sialic acids participate in a variety of recognition events including cell-cell, cell-extracellular matrix, and host-pathogen … e learning basildon hospitalWebJan 15, 2008 · Abstract. Sialic acids on vertebrate cell surfaces mediate many biological roles. Altered expression of certain sialic acid types or their linkages can have prognostic significance in human cancer. A classic but unexplained example is enhanced α2-6-sialylation on N-glycans resulting from overexpression of the Golgi enzyme β … food near buffalo bayou parkWebbinding reactivity to cell surface of lymphoma cells suggesting that neuraminidase removes cell surface sialic acid. In cell adhesion and invasion assays treatment with neuraminidase markedly enhanced cell adhesion to galectin-1 and decreased cell invasive capacity through galectin-1. α2,6-linked sialic acid may be involved in masking the ... food near buffalo airportWebAug 8, 2008 · Desialylation of ST6 Cells Increases Cell Adhesion to Galectin-3—To verify that α2-6 sialylation inhibits gal-3 binding, cells were treated with neuraminidase to remove sialic acids and then evaluated for binding to gal-3-coated plates.We first tested neuraminidase efficacy by monitoring the electrophoretic mobility of the β1 integrin … food near buckland hills mallWebNov 1, 2024 · Download Citation Regulation of cell adhesion to galectins by glycosylation: A new concept in lymphoma cell adhesion To investigate the biological roles of … food near buffalo ny