Glycogen accumulation and phase separation
WebWe found that glycogen accumulation is commonly present in the early stage of human and mouse liver tumors and essential for tumor initiation. Elimination of glycogen … WebMay 13, 2024 · Glycogen is a polysaccharide that comprises α-1,4-linked glucose backbone and α-1,6-linked glucose polymers at the branching points. It is widely found in organisms ranging from bacteria to eukaryotes. The physiological role of glycogen is not confined to being an energy reservoir and carbon source but varies depending on organisms. …
Glycogen accumulation and phase separation
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WebOct 21, 2024 · Europe PMC is an archive of life sciences journal literature. WebExpression of the glg operon and glycogen accumulation were carbon source- and growth phase-dependent, and were repressed by glucose. The highest intracellular glycogen …
WebOct 29, 2024 · Glycogen accumulation and phase separation drives liver tumor initiation through blocking Hippo signaling. A research paper based on the results titled … WebOct 21, 2024 · Europe PMC is an archive of life sciences journal literature.
WebMay 1, 2003 · Glycogen accumulation gradually decreased from 116 μg (glucose)(mg DW) −1 at D=0.07 h −1 to 42 μg (glucose) ... To study a possible relationship between G 1 phase duration and accumulation of trehalose and glycogen, their levels were measured after growing the cells asynchronously for 24 h in the fed-batch culture. WebSep 5, 2024 · Furthermore, additional studies identified novel roles of nuclear glycogenolysis as a supply of acetyl-CoA for epigenetic modulation (Sun et al, 2024), storage of glycogen in brown adipose fat mediated by gut microbiota (Li et al, 2024), and glycogen accumulation in liver cancer aiding in liquid–liquid phase separation fueling …
WebGlycogen accumulation and phase separation drives liver tumor initiation. Glucose consumption is generally increased in tumor cells to support tumor growth. Interestingly, we report that glycogen accumulation is a key initiating oncogenic event during liver malignant transformation. We found that glucose-6-phosphatase (G6PC) catalyzing the last ...
WebOct 6, 2024 · Glycogen phase separation drives liver tumor initiation: Organism: Mus musculus: Experiment type: Expression profiling by high throughput sequencing: … emv3-dセキュアWebOct 28, 2024 · Glycogen accumulation induces glycogen-Mst1/2 aggregate foci in cells, related to Figure 3 (A and B) Immunofluorescent staining of Mst1 (red) and DAPI ... emv 3d セキュアWebMay 29, 2024 · To maximize glycogen accumulation, we hypothesized that cells lacking key enzymes in the glycogen breakdown pathways would result in faster production and/or higher titers of glycogen. We considered three gene knockouts at two key nodes in glycogen metabolism: malQ, glgP , and agpA ( Figure 1B ). e mv2 とはWebDec 2, 2024 · Glycogen serves as a mobilized storage form of glucose predominantly found in the liver and skeletal muscle but also in the brain, heart, kidney, adipose tissue, … emv3dセキュアWebmaximum, a second phase of glycogen accumulation was observed in the heterocyst-free culture . Glycogen and nitrogenase activity in Anabaena 3149 100 0.5 0 10 20 30 0 10 30 emv 3dセキュアWebGlycogen storage disease type 1 (GSD1) is an inherited disorder caused by impaired glucose 6-phosphatase activity. ... levels in the postabsorptive phase and upon fasting. The G6Pase complex is composed of 2 subunits, that is, a catalytic ... hepatocytes are chronically stressed due to abnormal glycogen and lipid accumulation, which induce ... emv3dセキュア2.0WebGlycogen and lysosomal storage diseases affect multiple organ systems including the liver, skeletal muscle, heart, and brain and lead to the accumulation of large cytoplasmic inclusions (65, 66). It is therefore possible that nuclear deformation from intracellular stresses may contribute to disease progression in these cases as well. emv3dセキュア 2.0 サービス