Phenytoin and cimetidine
WebAfter five years' extensive use of cimetidine, drug interactions have emerged as one of its major adverse effects. Clinically important interactions with warfarin, phenytoin, diazepam, chlormethiazole, propranolol, lidocaine, and a number of other drugs have been reported. WebPhenytoin. Phenytoin is primarily metabolized via CYP2C9, 60 although CYP2C19 may also play a small role. 61 As stated above, cimetidine is a weak inhibitor of CYP2C9.
Phenytoin and cimetidine
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WebThere are 445 drugs known to interact with cimetidine, along with 4 disease interactions, and 3 alcohol/food interactions. Of the total drug interactions, 35 are major, 270 are moderate, and 140 are minor. Does cimetidine interact with my other drugs? Enter other medications to view a detailed report. ... WebAug 1, 2007 · Ritonavir (Norvir), a protease inhibitor and potent CYP3A4 inhibitor, is added to lopinavir (Kaletra) to boost serum levels in patients with human immunodeficiency virus. 14 Inducers increase...
WebFeb 2, 2024 · Phenytoin (Dilantin, Phenytek) is an antiseizure medication that has many possible interactions. This includes other seizure medications, antidepressants, and anticoagulants. Some phenytoin interactions lead to higher or lower levels of phenytoin. Higher levels of phenytoin can cause side effects like drowsiness or confusion. WebFeb 2, 2024 · Phenytoin (Dilantin, Phenytek) is an antiseizure medication that has many possible interactions. This includes other seizure medications, antidepressants, and anticoagulants. Some phenytoin interactions lead to higher or lower levels of phenytoin. …
WebCimetidine: Glucocorticoids . Methylprednisolone; Prednisone; Omeprazole (case reports with other proton pump inhibitors) Serotonin reuptake inhibitors ¶ Duloxetine; Fluoxetine; … WebAn 83-year-old man with a history of congestive heart failure is taking a number of prescription medications, including psyllium (Metamucil), digoxin (Lanoxin), phenytoin …
WebPhenytoin is used to control certain type of seizures, and to treat and prevent seizures that may begin during or after surgery to the brain or nervous system. Phenytoin is in a class …
WebOct 1, 2024 · Phenytoin Sodium injection capsules are approximately 90% bioavailable by the oral route. Phenytoin is 100% bioavailable by the IV route. For this reason, serum phenytoin concentrations may increase modestly when IV phenytoin is substituted for oral Phenytoin Sodium therapy. ... H2 antagonists (cimetidine), omeprazole: Sulfonamides ... the heber creeperWebCimetidine enters human breast milk and is actively transported by BCRP (breast cancer resistance protein). The percentage of the maternal dose ingested based on neonatal body weight is <10%, which should be safe under normal conditions. ... May reduce the hepatic metabolism of warfarin, phenytoin, propranolol, nifedipine, chlordiazepoxide ... the hebrew academy marlboro njWebDilantin Infatabs Oral, Dilantin-125 Oral, Lorantoin Oral. All generic drug interactions for phenytoin oral (lists will include brand and generic names): cimetidine oral brand names … the hebrew academy new cityWebyellowing of the skin or eyes. pain in upper right part of the stomach. excessive tiredness. unusual bruising or bleeding. small red or purple spots on skin. loss of appetite. flu-like symptoms. fever, sore throat, rash, mouth ulcers, or easy bruising, or facial swelling. Phenytoin injection may cause other side effects. the hebrew bible was written over quizletWebCimetidine, an H2-receptor antagonist, has been shown to inhibit the oxidative metabolism of several drugs by interacting with the hepatic cytochrome P450 system, which is involved in phase-I oxidative drug metabolism. Ranitidine, another H2-receptor antagonist, has been shown to have an extremely l … Famotidine: a notable lack of drug interactions the hebrew academy huntington beachWebCimetidine increases the risk of toxicity of other commonly used drugs such as phenytoin, diazepam, chlordiazepoxide, propranolol, theophylline, warfarin, and carbamazepine. Elderly patients taking cimetidine are at risk for neuropsychiatric changes, which may be temporarily reversed by physostigmine. the hebrew bible is also calledWeb• IV phenytoin incompatible in solution with many other drugs and with dextrose solution • Diazepam, isoniazid, cimetidine, and valproic acid increase levels of phenytoin • Alcohol use may either increase or decrease phenytoin levels • CNS depressants increase sedative effects • Phenobarbital and carbamazepine can decrease phenytoin ... the hebe foundation