WebFeb 2, 2024 · “These papers on PN chemistry – specifically phosphoryl guanidine linkages – demonstrate that we have identified an important new opportunity for optimizing … WebJun 11, 2024 · Recently, a new type of phosphate-modified nucleic acids, namely, phosphoryl guanidine oligonucleotides (PGO), has been described [7].A phosphoryl guanidine group can be easily introduced into any desired position of an oligonucleotide by standard automated phosphoramidite DNA synthesis [8].Further studies have uncovered a …
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WebPG-gapmers were designed containing three to four PG groups at both wings and a central “window” of seven deoxynucleotides with either phosphodiester or phosphorothioate … WebJun 11, 2024 · A phosphoryl guanidine group can be easily introduced into any desired position of an oligonucleotide by standard automated phosphoramidite DNA synthesis [8]. Further studies have uncovered a considerable potential of PGOs as biochemical probes [9] and for biosensors [10]. mario golf nes download
Control of backbone chemistry and chirality boost ... - PubMed
WebMar 16, 2024 · Herein, we report the synthesis and impact of stereopure phosphoryl guanidine-containing backbone linkages (PN linkages) to oligonucleotides acting through an RNase H-mediated mechanism, using ... Webphosphoryl guanidine (PG) modification of the phosphate group thathadbeendevelopedpreviously.29,30Recently,PGoligonucleotides (PGOs) have shown promise as primers for PCR,31,32 antibacterial33 and antiviral34 ASOs,andG-quadruplex-forming agents.35 Introduc-tion of a single PG group into a trinucleotide increased its … WebPhosphoryl guanidine oligo-2′- O -methylribonucleotides (2′-OMe PGOs) are a novel type of uncharged RNA analogues with high RNA affinity, which penetrate through the bacterial cell wall more efficiently. In this study, we investigated the uptake and biological effects of 2′-OMe PGO in mycobacteria. mario golf netplay