WebInhibition of DDX3X expression or activity reduces proliferation in cells from various tumor tissues, in particular in breast cancer, and its expression often correlates to tumor aggressiveness. This makes DDX3X a prominent candidate for the design. WebRK-33 is a potent and selective DDX3 inhibitor. RK-33 binds to DDX3 and abrogates its activity. Inhibition of DDX3 by RK-33 caused G1 cell cycle arrest, induced apoptosis, and …
Targeting DDX3 with a small molecule inhibitor for lung …
WebDDX3 Inhibitor RK-33 (IMAGE) Johns Hopkins Medicine. Caption. This is the structure of small DDX3 inhibitor RK-33. Credit. Venu Raman. Usage Restrictions. None. License. … WebProduct Inquiry. RK-33 (1070773-09-9) is an inhibitor of the RNA helicase DDX3 – IC 50 ’s = 4.4-8.4 µM in high DDX3 expressing lung cancer cell lines A549, H1299, H23, and H460. 1,2 Inhibition of DDX3 led to activation of cell death pathways, inhibition of Wnt pathway signaling, and abrogation of non-homologous end-joining (NHEJ) DNA repair. ifly luggage from walmart
RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box …
WebRK-33 is a DDX3 inhibitor. DDX3 has been identified as a RNA helicase that is overexpressed in various cancer types such as lung cancer and is correlated with lower survival in lung … WebInhibitor Molecular Weight 428.4 Inchi Key COUMZXFUZDBRCZ-UHFFFAOYSA-N ... DDX3X alleviates doxorubicin-induced cardiotoxicity by regulating Wnt/β-catenin signaling pathway in an in vitro model. View PDF. In Journal of Biochemical and Molecular Toxicology on 1 August 2024 by Feng, ... WebMar 23, 2024 · RK-33 is a small molecule inhibitor of host RNA helicase DDX3. Studies evaluated demographic, specialized medical, and also social chance final results, such as … ifly luggage promo code