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Rk33 ddx3x inhibitor

WebInhibition of DDX3X expression or activity reduces proliferation in cells from various tumor tissues, in particular in breast cancer, and its expression often correlates to tumor aggressiveness. This makes DDX3X a prominent candidate for the design. WebRK-33 is a potent and selective DDX3 inhibitor. RK-33 binds to DDX3 and abrogates its activity. Inhibition of DDX3 by RK-33 caused G1 cell cycle arrest, induced apoptosis, and …

Targeting DDX3 with a small molecule inhibitor for lung …

WebDDX3 Inhibitor RK-33 (IMAGE) Johns Hopkins Medicine. Caption. This is the structure of small DDX3 inhibitor RK-33. Credit. Venu Raman. Usage Restrictions. None. License. … WebProduct Inquiry. RK-33 (1070773-09-9) is an inhibitor of the RNA helicase DDX3 – IC 50 ’s = 4.4-8.4 µM in high DDX3 expressing lung cancer cell lines A549, H1299, H23, and H460. 1,2 Inhibition of DDX3 led to activation of cell death pathways, inhibition of Wnt pathway signaling, and abrogation of non-homologous end-joining (NHEJ) DNA repair. ifly luggage from walmart https://askerova-bc.com

RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box …

WebRK-33 is a DDX3 inhibitor. DDX3 has been identified as a RNA helicase that is overexpressed in various cancer types such as lung cancer and is correlated with lower survival in lung … WebInhibitor Molecular Weight 428.4 Inchi Key COUMZXFUZDBRCZ-UHFFFAOYSA-N ... DDX3X alleviates doxorubicin-induced cardiotoxicity by regulating Wnt/β-catenin signaling pathway in an in vitro model. View PDF. In Journal of Biochemical and Molecular Toxicology on 1 August 2024 by Feng, ... WebMar 23, 2024 · RK-33 is a small molecule inhibitor of host RNA helicase DDX3. Studies evaluated demographic, specialized medical, and also social chance final results, such as … ifly luggage promo code

Targeting DDX3 with a small molecule inhibitor for lung cancer ... - PubMed

Category:DDX3 acts as a tumor suppressor in colorectal cancer as loss of

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Rk33 ddx3x inhibitor

RK-33 CAS#1070773-09-9 MedKoo

WebRK-33 is a DDX3 inhibitor. DDX3 has been identified as a RNA helicase that is overexpressed in various cancer types such as lung cancer and is correlated with lower survival in lung … WebMar 12, 2024 · A DDX3X inhibitor may therefore provide effective treatment for patients with the DDX3X mutation. In conclusion, the newly developed RNA helicase assays for eIF4A3 …

Rk33 ddx3x inhibitor

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WebMar 27, 2015 · We identified a RNA helicase, DDX3, which is overexpressed in many cancer types including lung cancer and is associated with lower survival in lung cancer patients. … WebFeb 24, 2024 · RK-33 is a synthetic DDX3X inhibitor that specifically binds to the ATP-binding cleft of DDX3X and causes decreased unwinding activity. In lung cancer, RK-33 …

WebJun 1, 2024 · After adherence, DDX3 inhibition was achieved by transfection with 25 nmol/L siRNA targeting DDX3 or treatment with 2 μM RK33. SMARTpool ON-TARGETplus Human DDX3X siRNA [siRNA targeting DDX3 (siDDX3)] was acquired from Dharmacon (catalog number L-006874-02-0005), with the associated siRNA nontargeting scramble control … WebThese findings establish for the first time that RK-33 is a broad-spectrum antiviral agent that blocks DDX3X’ ... (Figure 2A, black); the extent of maximal inhibition of DDX3X …

WebApr 14, 2024 · Finally, cells were treated with 15 μM BaP+30 μM DBP for 24 h for further experiments. Prior to co-treatment with BaP and DBP co-treatment, macrophages were pre-treated with 10 μM of the NLRP3 inhibitor MCC950, or 10 μM CTSB inhibitor CA-074Me for 4 h to explore the role of NLRP3 or CTSB on macrophages polarization. 2.7. WebJan 9, 2024 · These findings establish for the first time that RK-33 is a broad-spectrum antiviral agent that blocks DDX3X's catalytic activities in vitro and limits viral replication in …

WebRK-33 (DDX3 inhibitor) CAS #1070773-09-9 Molecular Formula: C 23 H 20 N 6 O 3: Molecular Weight: 428.44 SYNONYM(S): ...

WebThese findings establish for the first time that RK-33 is a broad-spectrum antiviral agent that blocks DDX3X’s catalytic activities in vitro and limits viral replication in cells. Viral disease … iflylyonfrWebThe LV-DDX3X-RNAi lentiviral vector (GeneChem Co., Ltd., Shanghai, China) was transfected into SW480 and HCT116 cells to construct the DDX3 knockdown cell line. ... RK33 is a small molecule inhibitor of DDX3 that interferes with the helicase activity of DDX3 by docking with the ATP-binding gap of DDX3 . is staff training a direct or indirect costWebDec 1, 2024 · We use two small molecule inhibitors of DDX3, RK33 and 16D, with distinct inhibitory mechanisms that target DDX3′s ATPase activity and RNA helicase site ... In mammals, DDX3 is encoded by two highly homologous genes: X chromosomal DDX3X and Y chromosomal DDX3Y. This dsRNA helicase consists of two domains connected by a ... ifly luggage clearance walmartWebDDX3 is a DEAD box RNA helicase with oncogenic properties. RK-33 is developed as a small-molecule inhibitor of DDX3 and showed potent radiosensitizing activity in preclinical tumor models. This ... is staff welfare tax deductibleWebDownload scientific diagram DDX3 inhibitor RK-33. a. Structure of 5:7:5 tricyclic heterocycle RK-33. b. Graphic depiction of the interaction of DDX3 and RK-33 and the … ifly luggage reset lockWebThese findings establish for the first time that RK-33 is a broad-spectrum antiviral agent that blocks DDX3X's catalytic activities in vitro and limits viral replication in cells. KW - DDX3X. … ifly luggage warranty claimiflymail