Tfeb at the crossroads
Recent evidence suggests that infection with certain bacterial and viral pathogens causes TFEB, which is normally located in the cytoplasm, to translocate to the nucleus. There, it activates the transcription of genes that trigger the autophagy-lysosomal and inflammatory pathways to target intracellular pathogens. WebUpon cellular stress, TFEB is dephosphorylated and translocated to the nucleus, specifically binding to the coordinated lysosomal enhancement and regulation (CLEAR) motif to …
Tfeb at the crossroads
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Web1 May 2024 · TFEB regulates biological processes by modulating the expression of downstream genes. TFEB activity is tightly controlled by post-translational modifications … Web4 Apr 2024 · TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells. TFEB insufficiency promotes cardiac hypertrophy by blocking autophagic degradation of GATA4. Multifaceted activities of transcription factor EB in cancer onset and progression.
Web20 Aug 2024 · TFEB translocated from the cytosol to the nucleus in response to 15d-PGJ2. In normal conditions, TFEB is mainly localized in the cytosol in an inactive form [13,14,15, … Web21 Jul 2024 · TFEBexplorer is a comprehensive web-tool to study genes modulated by the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, that integrates multiple datasets following genetic perturbation of TFEB with experimentally validated and bioinformatically-predicted binding sites across multiple species.
WebThe transcription factor EB (TFEB) regulates energy homeostasis and cellular response to a wide variety of stress conditions, including nutrient deprivation, oxidative stress, organelle … Web1 Jul 2016 · TFEB has attracted a lot of attention owing to its ability to induce the intracellular clearance of pathogenic factors in a variety of murine models of disease, such as Parkinson's and Alzheimer's, suggesting that novel therapeutic strategies could be based on the modulation of TFEB activity.
WebWhen mTOR activity is inhibited by starvation or other conditions, no further phosphorylation of TFEB/TFE3 occurs; instead, they are dephosphorylated by the phosphatase calcineurin, leading to their nuclear translocation and activation ( Medina et al., 2015; Wang et al., 2015 ).
Web24 Nov 2015 · Subsequently, the drug-mediated induction of TFEB caused increase in lysosomal protein and the lysosomal abundance in cell. Collectively, this study reinforces the link between lysosomal biogenesis and lipid metabolism with TFEB at the crossroads. Furthermore, gemfibrozil may be of therapeutic value in the treatment of lysosomal … the gutter experts springfield moWeb1 Aug 2024 · TFEB - at the crossroads of host-pathogen interactions K. Keerti, A. Pant, Ravi Manjithaya Published 1 August 2024 Biology Journal of Cell Science The existence of … the gutter cover companyWeb4 Aug 2024 · To investigate whether itaconate, a metabolite that limits inflammation, is involved in the activation of TFEB, we treated phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 cells (Figure S1 A) and immortalized murine bone marrow derived macrophages (iBMDMs) with OI, a cell-permeable itaconate surrogate that is hydrolyzed … the barn at woodlake meadowsWeb6 Jan 2024 · Cardiovascular diseases (CVDs) are the leading cause of death and a major cause of disability globally. Transcription factor EB (TFEB), as a member of the … the gutter expertsWebAlthough TFEB is an emerging transcription factor in the field of immune signaling pathways, its role in infectious diseases remains contentious. Recent evidence suggests … the gutter doctor tauntonWeb29 Apr 2024 · Cross Roads By Good Night Inns is conveniently located on the outskirts of the historic town of Weedon, set back in its own rustic surroundings. It offers a restaurant, … the gutter estus flask shardWebIn folklore, crossroads may represent a location "between the worlds" and, as such, a site where supernatural spirits can be contacted and paranormal events can take place. … the gutter experts afton ny